E.L., a modern-day Phineas Gage: Revisiting frontal lobe injury.

ABSTRACT:

Background

How the prefrontal cortex (PFC) recovers its functionality following lesions remains a conundrum. Recent work has uncovered the importance of transient low-frequency oscillatory activity (LFO; < 4 Hz) for the recovery of an injured brain. We aimed to determine whether persistent cortical oscillatory dynamics contribute to brain capability to support 'normal life' following injury.

Methods

In this 9-year prospective longitudinal study (08/2012-2021), we collected data from the patient E.L., a modern-day Phineas Gage, who suffered from lesions, impacting 11% of his total brain mass, to his right PFC and supplementary motor area after his skull was transfixed by an iron rod. A systematic evaluation of clinical, electrophysiologic, brain imaging, neuropsychological an

SUBMITTER: de Freitas PHM 

PROVIDER: S-EPMC9903712 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature