Expanding the genomic encyclopedia of Actinobacteria with 824 isolate reference genomes.

ABSTRACT: The phylum Actinobacteria includes important human pathogens like Mycobacterium tuberculosis and Corynebacterium diphtheriae and renowned producers of secondary metabolites of commercial interest, yet only a small part of its diversity is represented by sequenced genomes. Here, we present 824 actinobacterial isolate genomes in the context of a phylum-wide analysis of 6,700 genomes including public isolates and metagenome-assembled genomes (MAGs). We estimate that only 30%-50% of projected actinobacterial phylogenetic diversity possesses genomic representation via isolates and MAGs. A comparison of gene functions reveals novel determinants of host-microbe interaction as well as environment-specific adaptations such as potential antimicrobial peptides. We identify plasmi

SUBMITTER: Seshadri R 

PROVIDER: S-EPMC9903846 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature