Invasive pneumococcal disease and long-term outcomes in children: A 20-year population cohort study.

ABSTRACT:

Background

Although vaccination against Streptococcus pneumoniae infections (such as invasive pneumococcal disease (IPD)) are available, challenges remain in prevention efforts. Moreover, downstream sequelae in children is relatively unknown. Thus, we aimed to evaluate short and long-term health outcomes among children with IPD.

Methods

Analysis of Streptococcus pneumoniae positive isolates from sterile body sites in children (0-17 years) in Alberta (Canada) from 1999 to 2019 was performed retrospectively (n=888). Cases were age and sex-matched to hospitalized population controls. Linkage to administrative health datasets was done to determine comorbidities and healthcare related outcomes. Cox proportional hazards were used to assess differences in time

SUBMITTER: Versluys KA 

PROVIDER: S-EPMC9903925 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature