Cortical myelin profile variations in healthy aging brain: A T1w/T2w ratio study.

ABSTRACT: Demyelination is observed in both healthy aging and age-related neurodegenerative disorders. While the significance of myelin within the cortex is well acknowledged, studies focused on intracortical demyelination and depth-specific structural alterations in normal aging are lacking. Using the recently available Human Connectome Project Aging dataset, we investigated intracortical myelin in a normal aging population using the T1w/T2w ratio. To capture the fine changes across cortical depths, we employed a surface-based approach by constructing cortical profiles traveling perpendicularly through the cortical ribbon and sampling T1w/T2w values. The curvatures of T1w/T2w cortical profiles may be influenced by differences in local myeloarchitecture and other tissue properties, which are known t

SUBMITTER: Sui YV 

PROVIDER: S-EPMC9904172 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature