The biology of TREM receptors.

ABSTRACT: Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages. These receptors have been implicated in inflammation, neurodegenerative diseases, bone remodelling, metabolic syndrome, atherosclerosis and cancer. Here, I review the structure, ligands, signalling modes and functions of TREMs in humans and mice and discuss the challenges that remain in understanding TREM biology.

SUBMITTER: Colonna M 

PROVIDER: S-EPMC9904274 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature