Rational design of Harakiri (HRK)-derived constrained peptides as BCL-x_L inhibitors.

ABSTRACT: Using the HRK BH3 domain, sequence hybridization and in silico methods we show dibromomaleimide staple scanning can be used to inform the design of BCL-x_L selective peptidomimetic ligands. These HRK-inspired reagents may serve as starting points for the discovery of therapeutics to target BCL-x_L-overexpressed cancers.

SUBMITTER: Zhang P 

PROVIDER: S-EPMC9904277 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature