Regulation of bone and fat balance by Fructus Ligustri Lucidi in ovariectomized mice.

ABSTRACT:

Context

Fructus Ligustri Lucidi (FLL), a commonly used herb of traditional Chinese medicine (TCM), is the fruit of Ligustrum lucidum Ait. (Oleaceae). The ethanol extract of FLL is a potential candidate for preventing and treating postmenopausal osteoporosis (PMOP) by nourishing the liver and kidneys.

Objective

This study determines whether an ethanol extract of FLL has anti-osteoporotic effects in ovariectomized (OVX) mice and explores the underlying mechanism.

Materials and methods

The OVX model of eight-week-old C57BL/6J female mice was taken, and ovariectomy was used as PMOP. Mice were divided into five groups: sham-operated group (n = 10), OVX group (n = 10), OVX + E₂ group (n = 10; 0.039 mg/kg), OVX + FLL group (n = 1

SUBMITTER: Qin X 

PROVIDER: S-EPMC9904306 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature