LAG-3⁺ tumor-infiltrating lymphocytes ameliorates overall survival in triple-negative breast cancer patients.

ABSTRACT:

Purpose

Immune checkpoint molecule lymphocyte-activating gene-3 (LAG-3), which is expressed on active lymphocytes, has proven to be associated with immunosuppression and cancer progression in a variety of solid tumors. However, the role of LAG-3⁺ lymphocytes in human breast cancer (BC) is still not conclusive. We therefore performed a meta-analysis to clarify the role of these cells in prognosis prediction for BC.

Methods

We searched PubMed, Embase, and EBSCO to identify the studies evaluating the association of LAG-3⁺ lymphocyte infiltration and overall survival (OS) and/or disease-free survival (DFS) in BC patients, then combined extracted data with STATA 12.0.

Results

Eight published studies involving 5,859 BC patients were incorporated into t

SUBMITTER: Hu G 

PROVIDER: S-EPMC9904386 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature