Small intestine and colon tissue-resident memory CD8⁺ T cells exhibit molecular heterogeneity and differential dependence on Eomes.

ABSTRACT: Tissue-resident memory CD8⁺ T (T_RM) cells are a subset of memory T cells that play a critical role in limiting early pathogen spread and controlling infection. T_RM cells exhibit differences across tissues, but their potential heterogeneity among distinct anatomic compartments within the small intestine and colon has not been well recognized. Here, by analyzing T_RM cells from the lamina propria and epithelial compartments of the small intestine and colon, we showed that intestinal T_RM cells exhibited distinctive patterns of cytokine and granzyme expression along with substantial transcriptional, epigenetic, and functional heterogeneity. The T-box transcription factor Eomes, which represses T_RM cell formation in some tissues,

SUBMITTER: Lin YH 

PROVIDER: S-EPMC9904390 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature