Effects of electroacupuncture on urinary metabolome and microbiota in presenilin1/2 conditional double knockout mice.

ABSTRACT:

Aim

The treatment of Alzheimer's disease (AD) is still a worldwide problem due to the unclear pathogenesis and lack of effective therapeutic targets. In recent years, metabolomic and gut microbiome changes in patients with AD have received increasing attention, and the microbiome-gut-brain (MGB) axis has been proposed as a new hypothesis for its etiology. Considering that electroacupuncture (EA) efficiently moderates cognitive deficits in AD and its mechanisms remain poorly understood, especially regarding its effects on the gut microbiota, we performed urinary metabolomic and microbial community profiling on EA-treated AD model mice, presenilin 1/2 conditional double knockout (PS cDKO) mice, to observe the effect of EA treatment on the gut microbiota in AD and find the connection

SUBMITTER: Gao J 

PROVIDER: S-EPMC9904445 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature