A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance.

ABSTRACT: Fasciola hepatica infection is responsible for substantial economic losses in livestock worldwide and poses a threat to human health in endemic areas. The mainstay of control in livestock and the only drug licenced for use in humans is triclabendazole (TCBZ). TCBZ resistance has been reported on every continent and threatens effective control of fasciolosis in many parts of the world. To date, understanding the genetic mechanisms underlying TCBZ resistance has been limited to studies of candidate genes, based on assumptions of their role in drug action. Taking an alternative approach, we combined a genetic cross with whole-genome sequencing to localise a ~3.2Mbp locus within the 1.2Gbp F. hepatica genome that confers TCBZ resistance. We validated this locus independently using bulk segrega

SUBMITTER: Beesley NJ 

PROVIDER: S-EPMC9904461 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature