Chloride-dependent mechanisms of multimodal sensory discrimination and nociceptive sensitization in Drosophila.

ABSTRACT: Individual sensory neurons can be tuned to many stimuli, each driving unique, stimulus-relevant behaviors, and the ability of multimodal nociceptor neurons to discriminate between potentially harmful and innocuous stimuli is broadly important for organismal survival. Moreover, disruptions in the capacity to differentiate between noxious and innocuous stimuli can result in neuropathic pain. Drosophila larval class III (CIII) neurons are peripheral noxious cold nociceptors and innocuous touch mechanosensors; high levels of activation drive cold-evoked contraction (CT) behavior, while low levels of activation result in a suite of touch-associated behaviors. However, it is unknown what molecular factors underlie CIII multimodality. Here, we show that the TMEM16/anoctamins subdued

SUBMITTER: Himmel NJ 

PROVIDER: S-EPMC9904763 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature