Metabolomic Signatures Associated With Pulmonary Arterial Hypertension Outcomes.

ABSTRACT:

Background

Pulmonary arterial hypertension (PAH) is a complex disease characterized by progressive right ventricular (RV) failure leading to significant morbidity and mortality. Investigating metabolic features and pathways associated with RV dilation, mortality, and measures of disease severity can provide insight into molecular mechanisms, identify subphenotypes, and suggest potential therapeutic targets.

Methods

We collected data from a prospective cohort of PAH participants and performed untargeted metabolomic profiling on 1045 metabolites from circulating blood. Analyses were intended to identify metabolomic differences across a range of common metrics in PAH (eg, dilated versus nondilated RV). Partial least squares discriminant analysis was first applied to assess the

SUBMITTER: Pi H 

PROVIDER: S-EPMC9904878 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature