House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model.

ABSTRACT:

Background

Asthma is a chronic inflammatory disease with structural changes in the lungs defined as airway remodelling. Mast cell responses are important in asthma as they, upon activation, release mediators inducing bronchoconstriction, inflammatory cell recruitment, and often remodelling of the airways. As guinea pigs exhibit anatomical, physiological, and pharmacological features resembling human airways, including mast cell distribution and mediator release, we evaluated the effect of extracts from two common allergens, house dust mite (HDM) and cat dander (CDE), on histopathological changes and the composition of tryptase- and chymase-positive mast cells in the guinea pig lungs.

Methods

Guinea pigs were exposed intranasally to HDM or CDE for 4, 8, and 12 weeks, and airw

SUBMITTER: Ramos-Ramirez P 

PROVIDER: S-EPMC9904926 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature