Dietary Factors and Early-Onset Colorectal Cancer in the United States-an Ecologic Analysis.

ABSTRACT:

Background

Incidence of early-onset colorectal cancer (EOCRC; e.g., diagnosed before age 50) in the United States has increased substantially since the 1990s but the underlying reasons remain unclear.

Methods

We examined the ecologic associations between dietary factors and EOCRC incidence in adults aged 25-49 during 1977-2016 in the United States, using negative binomial regression models, accounting for age, period, and race. The models also incorporated an age-mean centering (AMC) approach to address potential confounding by age. We stratified the analysis by sex and computed incidence rate ratio (IRR) for each study factor. Study factor data (for 18 variables) came from repeated national surveys; EOCRC incidence data came from the Surveillance Epidemiology, and End Resul

SUBMITTER: Chen J 

PROVIDER: S-EPMC9905219 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature