Opposite pattern of transcranial direct current stimulation effects in middle-aged and older adults: Behavioral and neurophysiological evidence.

ABSTRACT:

Introduction

Episodic memory (EM) exhibits an age-related decline, with overall increased impairment after the age of 65. The application of transcranial direct current stimulation (tDCS) to ameliorate cognitive decline in ageing has been extensively investigated, but its efficacy has been reported with mixed results. In this study, we aimed to assess whether age contributes to interindividual variability in tDCS efficacy.

Methods

Thirty-eight healthy adults between 50 and 81 years old received anodal tDCS over the left prefrontal cortex during images encoding and then performed an EM recognition task while event-related potentials (ERPs) were recorded.

Results

Our results showed an opposite pattern of effect between middle-aged (50-64 years) and older (65-81 years) a

SUBMITTER: Bagattini C 

PROVIDER: S-EPMC9905246 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature