Photodynamic nasal SARS-CoV-2 decolonization shortens infectivity and influences specific T-Cell responses.

ABSTRACT:

Background

The main objective was to evaluate the efficacy of intranasal photodynamic therapy (PDT) in SARS-CoV-2 mildly symptomatic carriers on decreasing the infectivity period. SARS-CoV-2-specific immune-stimulating effects and safety were also analysed.

Methods

We performed a randomized, placebo-controlled, clinical trial in a tertiary hospital (NCT05184205). Patients with a positive SARS-CoV-2 PCR in the last 48 hours were recruited and aleatorily assigned to PDT or placebo. Patients with pneumonia were excluded. Participants and investigators were masked to group assignment. The primary outcome was the reduction in in vitro infectivity of nasopharyngeal samples at days 3 and 7. Additional outcomes included safety assessment and quantification of humoral and T-ce

SUBMITTER: Fernandez-Montero A 

PROVIDER: S-EPMC9905247 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature