Nalmefene vs. dexmedetomidine for prevention of postoperative hyperalgesia in patients undergoing laparoscopic gynecological surgery with remifentanil infusion: A randomized double-blind controlled trial.

ABSTRACT: Intraoperative remifentanil infusion may paradoxically induce post-surgical hyperalgesia. Dexmedetomidine reportedly reduces opioid-induced hyperalgesia. Nalmefene selectively reverses several side-effects of opioids without impairing analgesia. Herein, this randomized, double-blind controlled trial investigated whether nalmefene, dexmedetomidine, and both drugs combined prevent remifentanil-induced hyperalgesia. One hundred and fifty patients undergoing elective laparoscopic gynecological surgery under desflurane anesthesia randomly received either intraoperative sufentanil 0.20 μg kg^-1 (Group S), or remifentanil 0.20 μg kg^-1 min^-1 (Group R), or remifentanil and pre-anesthesia nalmefene 0.20 μg kg^-1 (Group N), or remifentanil and pre-anesthesia

SUBMITTER: Jia Z 

PROVIDER: S-EPMC9905252 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature