Maternal vitamin D status modifies the effects of early life tobacco exposure on child lung function.

ABSTRACT:

Background

Prior studies suggest that vitamin D may modify the effects of environmental exposures; however, none have investigated gestational vitamin D and cumulative tobacco smoke exposure (TSE) throughout pregnancy and early life.

Objectives

This study investigated the effects of early life TSE on child lung function and the modulatory effects of gestational vitamin D on this association.

Methods

The VDAART (Vitamin D Antenatal Asthma Reduction Trial) recruited nonsmoking pregnant women and followed the mother-child pairs to age 6 years. TSE was assessed with questionnaires and plasma cotinine measurements in the mothers (10-18 and 32-38 gestational weeks) and children (1, 3, and 6 years). Cumulative TSE was calculated from the repeated cotinine measurements. 25-hy

SUBMITTER: Knihtila HM 

PROVIDER: S-EPMC9905288 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature