Genome-wide identification of murine interferon genes in microglial-mediated neuroinflammation in Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Shippy DC
PROVIDER: S-EPMC9905327 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Publications
Genome-wide identification of murine interferon genes in microglial-mediated neuroinflammation in Alzheimer's disease.
Shippy Daniel C DC Ulland Tyler K TK
Journal of neuroimmunology 20230121
Interferons play a major role in microglial-mediated neuroinflammation in Alzheimer's disease (AD). We investigated the interferon transcriptome (AD versus non-AD) using N9 and murine microglia. We identified 64 interferon-related differentially expressed genes (DEG) in LPS-stimulated N9 microglia versus control cells, 26 DEG in microglia from 5XFAD versus wild-type mice, with 13 DEG common to both datasets. Network analyses identified potential key mediators (Cxcl10, Ifit3) of the interferon re ...[more]
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