Effects of Flammulina velutipes polysaccharides on gut microbiota composition and metabolism in vitro fermentation.

ABSTRACT: Flammulina velutipes polysaccharides (FVP) exhibit many biological activities, but the effects on gut microflora and metabolism were still unclear. Here, we explored the composition of FVP, their influence on human gut microflora composition and metabolites. FVP were used to vitro fermentation through human fecal inoculums. In addition, 16S rRNA sequencing were used to assess the effects of FVP on the gut microbiota. The metabolic profiles were investigated using untargeted metabolomics approaches in the LC-MS platform. The results showed that FVP was mainly consisted of glucose, mannose, xylose, fucose and galactose. FVP is shown to increase the relative abundances of Bifidobacteriaceae, as well as Bacteroidaceae and remarkably decrease the numbers of genera Lachno

SUBMITTER: Su A 

PROVIDER: S-EPMC9905359 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature