Prognostic model construction and validation of esophageal cancer cellular senescence-related genes and correlation with immune infiltration.

ABSTRACT:

Introduction

Cellular senescence is a cellular response to stress, including the activation of oncogenes, and is characterized by irreversible proliferation arrest. Restricted studies have provided a relationship between cellular senescence and immunotherapy for esophageal cancer.

Methods

In the present study, we obtained clinical sample of colon cancer from the TCGA database and cellular senescence-related genes from MSigDB and Genecard datasets. Cellular senescence-related prognostic genes were identified by WGCNA, COX, and lasso regression analysis, and a cellular senescence-related risk score (CSRS) was calculated. We constructed a prognostic model based on CSRS. Validation was performed with an independent cohort that GSE53625. Three scoring systems for immuno-infiltrat

SUBMITTER: Zheng S 

PROVIDER: S-EPMC9905418 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature