The initial rate of tumour response to vismodegib treatment, can predict a complete response outcome for periocular LA-BCC.

ABSTRACT:

Purpose

To establish a model to predict treatment outcome of periocular locally advanced basal cell carcinoma (POLA BCC) based on initial response to treatment with vismodegib (Erivedge^TM), a sonic hedgehog inhibitor.

Design

Subgroup analysis of data from the STEVIE study database.

Methods

Analysis of medical history, treatment protocol, and treatment outcome of POLA BCC tumours in a STEVIE study population of 244 POLA BCC patients treated with ≥1 dose of vismodegib.

Results

A predictive model for complete response (CR) was established based on the initial treatment response. A cutoff value of 20% reduction in tumour size at 3 months of treatment identified the patients with a high probability (82.76%) to achieve CR. A second cutoff value of 67.7% re

SUBMITTER: Tiosano A 

PROVIDER: S-EPMC9905569 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature