Dataset Information

The alterations of corneal biomechanics in adult patients with corneal dystrophy.

ABSTRACT:

Purpose

To evaluate the changes of corneal biomechanics in granular, lattice and macular corneal dystrophy (GCD, LCD and MCD), and to assess the agreement of intraocular pressure (IOP) between Corvis ST tonometer (CST) and Goldmann applanation tonometer (GAT) and the agreement of central corneal thickness (CCT) between CST and ultrasound pachymeter (USP) in patients with corneal dystrophy.

Methods

Fifty-nine eyes with corneal dystrophy (26 eyes with GCD, 18 eyes with LCD and 15 eyes with MCD) and 48 eyes from healthy subjects were included in this study. All subjects received ocular examination and anterior segment photography under slit-lamp microscope. Corneal biomechanical parameters were obtained using CST. IOP and CCT were obtained using GAT and USP, respectively. Mixed-effects models were fitted for group comparisons and Bland-Altman analyses were applied for assessing the agreement of IOP or CCT between devices.

Results

GCD, LCD and MCD showed higher First Applanation Deformation Amplitude (A1DA) and Corvis Biomechanical Index (CBI), and a lower Stiffness Parameter at First Applanation (SPA1), compared to controls. After CCT adjustment, MCD group showed a higher A1DA compared to GCD or LCD. The IOP measured by CST demonstrated an overestimated bias to the one obtained by GAT in all groups. The CCT measured by CST and USP showed good agreement in healthy eyes but not in those with corneal dystrophy.

Conclusion

Corneal biomechanical alterations were observed in GCD, LCD and MCD. IOP and CCT measured by CST should be interpreted carefully in eyes with corneal dystrophy.

SUBMITTER: Wu M

PROVIDER: S-EPMC9905605 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Publications

The alterations of corneal biomechanics in adult patients with corneal dystrophy.

Wu Mengliang M Han Jing J Wang Xiaochun X Shao Tingting T Wang Yan Y

Eye (London, England) 20220216 3

<h4>Purpose</h4>To evaluate the changes of corneal biomechanics in granular, lattice and macular corneal dystrophy (GCD, LCD and MCD), and to assess the agreement of intraocular pressure (IOP) between Corvis ST tonometer (CST) and Goldmann applanation tonometer (GAT) and the agreement of central corneal thickness (CCT) between CST and ultrasound pachymeter (USP) in patients with corneal dystrophy.<h4>Methods</h4>Fifty-nine eyes with corneal dystrophy (26 eyes with GCD, 18 eyes with LCD and 15 ey ...[more]

PMID: 35173270

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Dataset Information

The alterations of corneal biomechanics in adult patients with corneal dystrophy.

Purpose

Methods

Results

Conclusion

Publications

The alterations of corneal biomechanics in adult patients with corneal dystrophy.

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