Synthesis of pyrimidines from dinitrogen and carbon.

ABSTRACT: The element nitrogen and nitrogenous compounds are vital to life. The synthesis of nitrogen-containing compounds using dinitrogen as the nitrogen source, not through ammonia, is of great interest and great value but remains a grand challenge. Herein, we describe a strategy to realize this transformation by combining the heterogeneous approach with the homogeneous methodology. The N₂ molecule was first fixed with carbon and LiH through a one-pot heterogeneous process, forming Li₂CN₂ as an 'activated' nitrogen source with high efficiency. Then subsequent homogeneous treatments of Li₂CN₂ to construct the organic synthon carbodiimide and the RNA/DNA building block pyrimidines were fulfilled. By using ¹⁵N₂ as the feeds

SUBMITTER: Shi X 

PROVIDER: S-EPMC9905645 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature