The pharmacokinetic and residue depletion study of eugenol in carp (Cyprinus carpio).

ABSTRACT:

Introduction

The pharmacokinetic profile and residue depletion of eugenol in carp (Cyprinus carpio) tissues and plasma were performed by a convenient and reliable high-performance liquid chromatography (HPLC) method.

Methods

The eugenol in carp tissues and plasma was extracted with a mixed solution of acetonitrile and methanol. N-hexane was used to remove lipid impurities. The method was successfully applied to the pharmacokinetic and residue elimination of eugenol in carp after the carp was administered a medicated bath.

Results

The average recoveries of eugenol in tissues and plasma fortified with four concentration levels were 69.0-106.6% and 80.0-86.7%, respectively. The relative standard deviations were < 8.9%. The limit of detection (LOD) was 0.01 μg/g in

SUBMITTER: Xu Y 

PROVIDER: S-EPMC9905725 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature