No genetic causal association between Alzheimer's disease and osteoporosis: A bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Objective

Many observational studies have found an association between Alzheimer's disease (AD) and osteoporosis. However, it is unclear whether there is causal genetic between osteoporosis and AD.

Methods

A two-sample Mendelian randomization (MR) study was used to investigate whether there is a causal relationship between osteoporosis and AD. Genes for osteoporosis and AD were obtained from published the genome-wide association studies (GWAS). Single nucleotide polymorphisms (SNPs) with significant genome-wide differences (p < 5 × 10^-8) and independent (r ² < 0.001) were selected, and SNPs with F ≥ 10 were further analyzed. Inverse variance weighted (IVW) was used to assess causality, and the results were reported as odds ratios (O

SUBMITTER: Hu H 

PROVIDER: S-EPMC9905740 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature