Degeneracy and stability in neural circuits of dopamine and serotonin neuromodulators: A theoretical consideration.

ABSTRACT: Degenerate neural circuits perform the same function despite being structurally different. However, it is unclear whether neural circuits with interacting neuromodulator sources can themselves degenerate while maintaining the same neuromodulatory function. Here, we address this by computationally modeling the neural circuits of neuromodulators serotonin and dopamine, local glutamatergic and GABAergic interneurons, and their possible interactions, under reward/punishment-based conditioning tasks. The neural modeling is constrained by relevant experimental studies of the VTA or DRN system using, e.g., electrophysiology, optogenetics, and voltammetry. We first show that a single parsimonious, sparsely connected neural circuit model can recapitulate several separate experimental findings that

SUBMITTER: Behera CK 

PROVIDER: S-EPMC9905743 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature