Exploring the mechanism of Cassiae semen in regulating lipid metabolism through network pharmacology and experimental validation.

ABSTRACT:

Background

Multiple studies have assessed the role of Cassiae semen (CS) in regulating lipid metabolism. However, the mechanism of action of CS on non-alcoholic fatty liver disease (NAFLD) has seen rare scrutiny.

Objective

The objective of this study was to explore the regulatory mechanism of CS on lipid metabolism in NAFLD.

Methods

Components of CS ethanol extract (CSEE) were analyzed and identified using UPLC-Q-Orbirap HRMS. The candidate compounds of CS and its relative targets were extracted from the Traditional Chinese Medicine Systems Pharmacology, Swiss-Target-Prediction, and TargetNet web server. The Therapeutic Target Database, Genecards, Online Mendelian Inheritance in Man, and DisGeNET were searched for NAFLD targets. Binding affinity between potential core

SUBMITTER: Huang L 

PROVIDER: S-EPMC9905789 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature