Comparison of Risk Allele Frequencies of Psoriasis-Associated Single-Nucleotide Polymorphisms in Different Population Groups.

ABSTRACT:

Background

The prevalence of psoriasis differs by population, and it appears to be more common among Europeans than in East Asians. Recent genome-wide association studies (GWAS) have identified alleles that increase the risk of psoriasis, and these alleles may present different frequencies in different geographic regions.

Objective

We aimed to gain insights into the causes of differences in disease frequencies according to populations and the factors affecting prevalence and pattern differences.

Methods

We collected a total of 147 psoriasis-associated single-nucleotide polymorphisms (SNPs) from the GWAS catalog and compared the allele frequency differences in 27 populations using public population frequency in the 1000 Genomes Project phase 3 (n=2,504) and the Korean

SUBMITTER: Lee D 

PROVIDER: S-EPMC9905865 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature