Polygenic risk of any, metastatic, and fatal prostate cancer in the Million Veteran Program.

ABSTRACT:

Background

Genetic scores may provide an objective measure of prostate cancer risk and thus inform screening decisions. We evaluated whether a polygenic hazard score based on 290 genetic variants (PHS290) is associated with prostate cancer risk in a diverse population, including Black men, who have higher average risk of prostate cancer death but are often treated as a homogeneously high-risk group.

Methods

This was a retrospective analysis of the Million Veteran Program, a national, population-based cohort study of US military veterans conducted 2011-2021. Cox proportional hazards analyses tested for association of genetic and other risk factors (including self-reported race and ethnicity and family history) with age at death from prostate cancer, age at diagnosis of metast

SUBMITTER: Pagadala MS 

PROVIDER: S-EPMC9905969 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature