Clusterin is a biomarker of breast cancer prognosis and correlated with immune microenvironment.

ABSTRACT:

Background

It has been established that clusterin is involved in the invasion of immune cells in the tumor microenvironment, but it remains unknown how it promotes immune invasion in breast cancer.

Methods

We used Tumor Immune Estimation Resource (TIMER) and Gene Expression Profiling Interactive Analysis (GEPIA) databases to assess the relation between expression of clusterin and immunoinfiltration-related marker genes. TIMER database was used to evaluate the expression of clusterin, and its relation to tumor immune invasion was examined. Based on Kaplan-Meier plotter database, we investigated the association between clusterin expression and prognosis in patients with cancer, and the impact of clinicopathological factors and cancer-related outcomes.

Results

Clusterin

SUBMITTER: Yang P 

PROVIDER: S-EPMC9906057 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature