miR-135a inhibits the proliferation of HBV-infected hepatocellular carcinoma cells by targeting HOXA10.

ABSTRACT:

Background

The incidence of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) is extremely high. MicroRNAs (miRNAs) are a type of endogenous non-coding small RNA with novel molecular therapeutic mechanisms that plays an important role in the occurrence and development of cancers. This study aimed to explore the regulation mechanism of miR-135a and HOXA10 in the proliferation, invasion, and apoptosis of HCC cells.

Methods

Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis was used to detect the expression level of miR-135a. Overexpression of miR-135a was used to measure the roles of miR-135a in the proliferation, invasion, and apoptosis of HCC cells. A dual luciferase experiment wa

SUBMITTER: Lin J 

PROVIDER: S-EPMC9906062 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature