CASZ1 promotes migration, invasion, and metastasis of lung cancer cells by controlling expression of ITGAV.

ABSTRACT: CASZ1, a zinc finger transcription factor with two isoforms, is known to play important roles in cardiac and neural development. The abnormal expression of CASZ1 is also frequently found in a variety of tumors but has different effects on different tumors; for example, it acts as a tumor suppressor in neuroblastoma but promotes cancer metastasis in ovarian cancer. However, the effect of CASZ1 in lung cancer, the most lethal cancer, remains unclear. Here, we found that the expression of CASZ1 in lung cancer is positively associated with cancer metastasis and poor prognosis. The overexpression of CASZ1b promotes lung cancer cell migration, invasion, and epithelial-mesenchymal transition and is associated with poor prognosis in lung cancer patients. The knockdown of CASZ1 resulted in the supp

SUBMITTER: Taheri Baghmisheh S 

PROVIDER: S-EPMC9906072 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature