Von Willebrand factor in experimental malaria-associated acute respiratory distress syndrome.

ABSTRACT:

Background

Malaria-associated acute respiratory distress syndrome (MA-ARDS) is a lethal complication of severe malaria, characterized by marked pulmonary inflammation. Patient studies have suggested a link between von Willebrand factor (VWF) and malaria severity.

Objectives

To investigate the role of VWF in the pathogenesis of experimental MA-ARDS.

Methods

Plasmodium berghei NK65-E (PbNK65) parasites were injected in Vwf^+/+ and Vwf^-/- mice. Pathological parameters were assessed following infection.

Results

In accordance with patients with severe malaria, plasma VWF levels were increased and ADAMTS13 activity levels were reduced in experimental MA-ARDS. ADAMTS13- and plasmin-independent reductions of high molecular weight VWF multimers were

SUBMITTER: Kraisin S 

PROVIDER: S-EPMC9906160 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature