Locus coeruleus and dorsal cingulate morphology contributions to slowed processing speed.

ABSTRACT: Slowed information processing speed is a defining feature of cognitive aging. Nucleus locus coeruleus (LC) and medial prefrontal regions are targets for understanding slowed processing speed because these brain regions influence neural and behavioral response latencies through their roles in optimizing task performance. Although structural measures of medial prefrontal cortex have been consistently related to processing speed, it is unclear if 1) declines in LC structure underlie this association because of reciprocal connections between LC and medial prefrontal cortex, or 2) if LC declines provide a separate explanation for age-related changes in processing speed. LC and medial prefrontal structural measures were predicted to explain age-dependent individual differences in processing spee

SUBMITTER: Eckert MA 

PROVIDER: S-EPMC9906468 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature