Sex steroid hormones in depressive disorders as a basis for new potential treatment strategies.

ABSTRACT: The sex steroid hormones (SSHs) such as testosterone, estradiol, progesterone, and their metabolites have important organizational and activational impacts on the brain during critical periods of brain development and in adulthood. A variety of slow and rapid mechanisms mediate both organizational and activational processes via intracellular or membrane receptors for SSHs. Physiological concentrations and distribution of SSHs in the brain result in normal brain development. Nevertheless, dysregulation of hormonal equilibrium may result in several mood disorders, including depressive disorders, later in adolescence or adulthood. Gender differences in cognitive abilities, emotions as well as the 2-3 times higher prevalence of depressive disorders in females, were already described. This impl

SUBMITTER: Pillerova M 

PROVIDER: S-EPMC9906660 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature