Tumor Targeting of ²¹¹At-Labeled Antibody under Sodium Ascorbate Protection against Radiolysis.

ABSTRACT: Astatine-211 (²¹¹At) is an alpha emitter applicable to radioimmunotherapy (RIT), a cancer treatment that utilizes radioactive antibodies to target tumors. In the preparation of ²¹¹At-labeled monoclonal antibodies (²¹¹At-mAbs), the possibility of radionuclide-induced antibody denaturation (radiolysis) is of concern. Our previous study showed that this ²¹¹At-induced radiochemical reaction disrupts the cellular binding activity of an astatinated mAb, resulting in attenuation of in vivo antitumor effects, whereas sodium ascorbate (SA), a free radical scavenger, prevents antibody denaturation, contributing to the maintenance of binding and antitumor activity. However, the influence of antibody denaturation on the pharmacokinetics of ²¹¹

SUBMITTER: Takashima H 

PROVIDER: S-EPMC9906747 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature