Altered glycosylation profiles of serum IgG in Takayasu arteritis.

ABSTRACT:

Background

Takayasu arteritis (TAK) is an autoimmune inflammatory disorder with an undefined etiology. This study aimed to characterize the glycosylation profiles of serum immunoglobulin G (IgG) in patients with TAK.

Methods

Lectin microarrays containing 56 types of lectins were used to detect the glycan levels of serum IgG in 164 patients with TAK, 128 patients with atherosclerosis used as disease controls (DCs), and 100 healthy controls (HCs). Differentially altered glycosylation patterns between TAK and control groups as well as between TAK subgroups were identified and further validated by lectin blot. The classification performance of the TAK-specific glycosylation change was measured by receiver-operating characteristic (ROC) curve analysis.

Results

Lectin micro

SUBMITTER: Liu L 

PROVIDER: S-EPMC9906894 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature