Cold exposure alters lipid metabolism of skeletal muscle through HIF-1α-induced mitophagy.

ABSTRACT:

Background

In addition to its contractile properties and role in movement, skeletal muscle plays an important function in regulating whole-body glucose and lipid metabolism. A central component of such regulation is mitochondria, whose quality and function are essential in maintaining proper metabolic homeostasis, with defects in processes such as autophagy and mitophagy involved in mitochondria quality control impairing skeletal muscle mass and function, and potentially leading to a number of associated diseases. Cold exposure has been reported to markedly induce metabolic remodeling and enhance insulin sensitivity in the whole body by regulating mitochondrial biogenesis. However, changes in lipid metabolism and lipidomic profiles in skeletal muscle in response to cold exposure ar

SUBMITTER: Chen W 

PROVIDER: S-EPMC9906913 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature