Genomic features and its potential implication in bone oligometastatic NSCLC.

ABSTRACT:

Objectives

Emerging evidence have demonstrated that oligometastatic non-small cell lung cancer (NSCLC) can achieve clinical benefit from local consolidative therapy. Bone oligometastasis is common in advanced lung cancer, but little is known about its molecular features. The purpose of our study aimed to investigate the genomic landscape bone oligometastatic NSCLC.

Methods

We collected paired blood and tissue samples from 31 bone oligometastatic NSCLC patients to make a comprehensive analysis of mutations by performing next-generation sequencing.

Results

A total of 186 genomic mutations were detected from 105 distinct cancer-relevant genes, with a median number of 6 alterations per tumor. The most frequently mutated genes were EGFR (58%) and TP53 (55%), followed by KR

SUBMITTER: Liao R 

PROVIDER: S-EPMC9906959 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature