Competing endogenous RNA network analysis of the molecular mechanisms of ischemic stroke.

ABSTRACT:

Background

Ischemic stroke (IS) is a serious neurological disease that largely results in long-term disability and death. Extensive evidence has indicated that the activation of inflammation and ferroptosis significantly contribute to the development of IS pathology. However, the underlying molecular mechanism remains unclear. In this study, we aimed to identify potential biomarkers associated with IS through the construction of a competing endogenous RNA (ceRNA) network and to investigate the possible inflammatory and ferroptosis-related molecular mechanisms.

Results

We identified 178 differentially expressed target messenger RNAs (DETmRNAs) associated with IS. As revealed through enrichment analysis, the DEmRNAs were mainly enriched in the inflammatory signaling pathways a

SUBMITTER: Chen JM 

PROVIDER: S-EPMC9906963 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature