Associations between reproductive history, hormone use, <i>APOE</i> ε4 genotype and cognition in middle- to older-aged women from the UK Biobank.

ABSTRACT:

Introduction

Relative to men, women are at a higher risk of developing age-related neurocognitive disorders including Alzheimer's disease. While women's health has historically been understudied, emerging evidence suggests that reproductive life events such as pregnancy and hormone use may influence women's cognition later in life.

Methods

We investigated the associations between reproductive history, exogenous hormone use, apolipoprotein (APOE) ε4 genotype and cognition in 221,124 middle- to older-aged (mean age 56.2 ± 8.0 years) women from the UK Biobank. Performance on six cognitive tasks was assessed, covering four cognitive domains: episodic visual memory, numeric working memory, processing speed, and executive function.

Results

A longer reproductive span,

SUBMITTER: Lindseth LRS 

PROVIDER: S-EPMC9907169 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature