Binding peptide generation for MHC Class I proteins with deep reinforcement learning.

ABSTRACT:

Motivation

MHC Class I protein plays an important role in immunotherapy by presenting immunogenic peptides to anti-tumor immune cells. The repertoires of peptides for various MHC Class I proteins are distinct, which can be reflected by their diverse binding motifs. To characterize binding motifs for MHC Class I proteins, in vitro experiments have been conducted to screen peptides with high binding affinities to hundreds of given MHC Class I proteins. However, considering tens of thousands of known MHC Class I proteins, conducting in vitro experiments for extensive MHC proteins is infeasible, and thus a more efficient and scalable way to characterize binding motifs is needed.

Results

We presented a de novo generation framework, coined PepPPO, to characterize binding motif for

SUBMITTER: Chen Z 

PROVIDER: S-EPMC9907221 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature