Preconception paternal alcohol exposure decreases IVF embryo survival and pregnancy success rates in a mouse model.

ABSTRACT: Increasingly, couples struggling with fertility turn to assisted reproductive techniques, including IVF, to have children. Despite the demonstrated influence of periconception male health and lifestyle choices on offspring development, studies examining IVF success rates and child health outcomes remain exclusively focused on maternal factors. Using a physiologically relevant mouse model, we tested the hypothesis that chronic paternal preconception alcohol intake adversely affects IVF success and negatively impacts IVF offspring fetoplacental growth. Using a voluntary, binge-like mouse model, we exposed sexually mature C57BL/6J males to three preconception treatments (0% (Control), 6% EtOH or 10% EtOH) for 6 weeks, isolated and cryopreserved caudal sperm from treated males, and then used t

SUBMITTER: Roach AN 

PROVIDER: S-EPMC9907225 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature