Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression.

ABSTRACT:

Background

Aberrant activation of the WNT/β-catenin and STAT3 signaling pathways plays a critical role in cancer progression. However, direct targeting of these pathways as an anti-cancer therapeutic approach needs to be reconsidered due to its serious side effects. Here, we demonstrate that overexpression of WNT induces STAT3 activation in a galectin-3-dependent manner.

Methods

We investigated how galectin-3 mediates the crosstalk between WNT/β-catenin and STAT3 signaling and whether inhibition of galectin-3 can reduce gastric cancer. The molecular mechanisms were analyzed by biochemical assays using cultured gastric cancer cells, patient tissues, and genetically engineered mice. Moreover, we confirm of therapeutic effects of GB1107, a cell-penetrating galectin-3 specific i

SUBMITTER: Kim SJ 

PROVIDER: S-EPMC9907361 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature