The association of coagulation and atrial fibrillation: a systematic review and meta-analysis.

ABSTRACT:

Aims

While atrial fibrillation (AF) is suggested to induce a prothrombotic state, increasing thrombotic risk, it is also hypothesized that coagulation underlies AF onset. However, conclusive evidence is lacking. With this systematic review and meta-analysis, we aimed to summarize and combine the evidence on the associations between coagulation factors with AF in both longitudinal and cross-sectional studies.

Methods and results

We systematically searched for longitudinal cohort and cross-sectional studies investigating AF and thrombosis. For longitudinal studies, pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated. For cross-sectional studies, we determined pooled standardized mean differences (SMDs) and 95% CIs. A total of 17 longitudinal and 44 cr

SUBMITTER: Tilly MJ 

PROVIDER: S-EPMC9907526 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature