Exhaled Mycobacterium tuberculosis Predicts Incident Infection in Household Contacts.

ABSTRACT:

Background

Halting transmission of Mycobacterium tuberculosis (Mtb) by identifying infectious individuals early is key to eradicating tuberculosis (TB). Here we evaluate face mask sampling as a tool for stratifying the infection risk of individuals with pulmonary TB (PTB) to their household contacts.

Methods

Forty-six sputum-positive PTB patients in The Gambia (August 2016-November 2017) consented to mask sampling prior to commencing treatment. Incident Mtb infection was defined in 181 of their 217 household contacts as QuantiFERON conversion or an increase in interferon-γ of ≥1 IU/mL, 6 months after index diagnosis. Multilevel mixed-effects logistical regression analysis with cluster adjustment by household was used to identify predictors of incident infection.

Results</

SUBMITTER: Williams CM 

PROVIDER: S-EPMC9907542 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature