Pathogens Identified by Minimally Invasive Tissue Sampling in India and Pakistan From Preterm Neonatal Deaths: The PURPOSE Study.

ABSTRACT:

Background

We identified pathogens found in internal organs and placentas of deceased preterm infants cared for in hospitals in India and Pakistan.

Methods

Prospective, observational study conducted in delivery units and neonatal intensive care units. Tissue samples from deceased neonates obtained by minimally invasive tissue sampling and placentas were examined for 73 different pathogens using multiplex polymerase chain reaction (PCR).

Results

Tissue for pathogen PCR was obtained from liver, lung, brain, blood, cerebrospinal fluid, and placentas from 377 deceased preterm infants. Between 17.6% and 34.1% of each type of tissue had at least 1 organism identified. Organism detection was highest in blood (34.1%), followed by lung (31.1%), liver (23.3%), cerebrospinal flu

SUBMITTER: Ghanchi NK 

PROVIDER: S-EPMC9907547 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature