Continuous Rather Than Solely Early Farm Exposure Protects From Hay Fever Development.

ABSTRACT:

Background

An important window of opportunity for early-life exposures has been proposed for the development of atopic eczema and asthma.

Objective

However, it is unknown whether hay fever with a peak incidence around late school age to adolescence is similarly determined very early in life.

Methods

In the Protection against Allergy-Study in Rural Environments (PASTURE) birth cohort potentially relevant exposures such as farm milk consumption and exposure to animal sheds were assessed at multiple time points from infancy to age 10.5 years and classified by repeated measure latent class analyses (n = 769). Fecal samples at ages 2 and 12 months were sequenced by 16S rRNA. Hay fever was defined by parent-reported symptoms and/or physician's diagnosis of hay fever in the

SUBMITTER: Pechlivanis S 

PROVIDER: S-EPMC9907754 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature